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Publications
Improving the precision of QT measurements (248 KB)
Borje Darpo, Anthony A. Fossa, Jean-Philippe Couderc, Meijian Zhou, Anna Schreyer, Mark Ticktin, Alex Zapesochny
Assessing QT prolongation and electrocardiography
restitution using a beat-to-beat method (760 KB)
Anthony A. Fossa, Meijian Zhou
Measurement and Regulation of Cardiac Ventricular Repolarization: From the QT Interval to Repolarization Morphology (296 KB)
Jean-Philippe Couderc
An Update on QT Measurement and Interpretation Methodologies (56 KB)
Jean-Philippe Couderc, Wojciech Zareba
Cardiac Regulation and Electrographic Factors Contributing to the Measurement of Repolarization Variability (412 KB)
Jean-Philippe Couderc
ECG Parameters and Exposure to Carbon Ultrafine Particles in Young Healthy Subjects (800 KB)
Wojciech Zareba, Jean Philippe Couderc, Günter Oberdörster, David Chalupa, Christopher Cox, Li-Shan Huang, Annette Peters, Mark J. Utell, and Mark W. Frampton
Baseline Values and Sotalol-Induced Changes of Ventricular
Repolarization Duration, Heterogeneity, and Instability in
Patients With a History of Drug-Induced Torsades de Pointes (196 KB)
Jean-Philippe Couderc, PhD, MBA, Stefan Kaab, MD, PhD,
Martin Hinterseer, MD, Scott McNitt, MS, Xiaojuan Xia, MS,
Anthony Fossa, PhD, Britt M. Beckmann, MD, Slava Polonsky, MS, and Wojciech Zareba, MD, PhD, FACC
Comparison of Highly-Automatic versus FDA-Submitted
QT Measurementsfor the Detection of Moxifloxacin Induced
Prolongation of the QTc Interval (242 KB)
R Handzel, C Garnett, M Li, S McNitt, S Polonski, X Xia, JP Couderc
The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships (403 KB)
Anthony A. Fossa
Investigating the effect of sotalol on the
repolarization intervals in healthy young individuals (469 KB)
Jean-Philippe Couderc, PhD, Meijian Zhou, PhD,
Nenad Sarapa, MD, Wojciech Zareba, MD, PhD
Improving the Detection of Subtle IKr-Inhibition
Assessing Electrocardiographic Abnormalities of
Repolarization Induced by Moxifloxacin (273 KB)
Jean-Philippe Couderc, Scott McNitt, Ollivier Hyrien, Martino Vaglio, Xiajuan Xia, Slava Polonsky, Arthur J. Moss1 and Wojciech Zareba
QT Prolongation Modifies Dynamic Restitution and Hysteresis
of the Beat-to-Beat QT-TQ Interval Relationship during Normal
Sinus Rhythm under Varying States of Repolarization (742 KB)
Anthony A. Fossa, Todd Wisialowski, and Kimberly Crimin
Dynamic Beat-to-Beat Modeling of the QT-RR Interval
Relationship: Analysis of QT Prolongation during Alterations of
Autonomic State versus Human Ether a-go-go-Related Gene
Inhibition (2,272 KB)
Anthony A. Fossa, Todd Wisialowski, Anthony Magnano, Eric Wolfgang, Roxanne Winslow, William Gorczyca, Kimberly Crimin, and David L. Raunig
Impaired T-Amplitude Adaptation to Heart Rate Characterizes
IKr Inhibition in the Congenital and Acquired Forms
of the Long QT Syndrome (218kb)
JP Couderc, S McNitt, J Xia, W Zareba, A Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA
Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval (257kb)
JP Couderc, S McNitt, J Xia, W Zareba, A Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA
T-wave Morphology and Arrhythmic Events in Patients with Dilated Cardiomyopathy (194kb)
JP Couderc, W Zareba, X Xia, M Andrew, AJ Moss Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA
Fractionated Repolarization Induced by Sotalol in Healthy Subjects (103kb)
M Vaglio, JP Couderc, X Xia, W Zareba
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA
QT beat-to-beat Repolarization Variability in LQTS Patients with the SCN5A Sodium Channel Gene Mutation (677kb)
JP Couderc, W Zareba, AJ Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA
Drug-induced Changes of Ventricular Repolarization: New Incentives for Quantifying T wave Morphology (134kb)
JP Couderc, W Zareba, AJ Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA
Discrimination of HERG Carrier from Non-Carrier
Adult Patients with Borderline Prolonged QTc Interval (108kb)
JP Couderc, W Zareba, AJ Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA
PDF (195kb)
An editorial in the January 2006 issue of the Annals of Noninvasive Electrocardiology, prepared by Dr. Arthur J. Moss, describing the historical background and current thinking in the quantification of cardiac safety using QT interval measurements titled “Drug-Induced QT Prolongation: An Update.”
PDF (161kb)
An article by Drs. Couderc, Zareba, Moss et. al in the January 2005 issue of Annals of Noninvasive Electrocardiology describing the most robust method for determining an individual-based correction for QT interval titled “Assessment of the Stability of the individual-based Correction of QT interval for heart rate.”
PDF (218kb)
An article by Drs. Couderc, Zareba, Moss et. al in the Journal of Electrocardiology describing more advanced ECG markers titled “Identification of Sotalol-induced Changes
in Repolarization With T Wave Areabased Repolarization Duration Parameters.”
Links
PDF (67kb)
FDA Guidance Document for QT Measurement in Clinical Trials Titled “Guidance for Industry: E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs.”
PDF (71kb)
FDA Guidance Document for Non Clinical Evaluation of Cardiac Risk in Clinical Trials Titled “Guidance for Industry: S7B Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals.”
View QT drug lists on the University of Arizona's CERT site
Drugs that Prolong the QT Interval and/or Induce Torsades de Pointes Ventricular Arrhythmia
PDF (67kb)
ICH E14 Q&A E14 Implementation Working Group - Questions & Answers
PDF (25kb)
QT IRT Reference Document
PDF (36kb)
QT IRT MAPP
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