Baseline Values and Sotalol-Induced Changes of Ventricular
Repolarization Duration, Heterogeneity, and Instability in
Patients With a History of Drug-Induced Torsades de Pointes (196 KB)
Jean-Philippe Couderc, PhD, MBA, Stefan Kaab, MD, PhD,
Martin Hinterseer, MD, Scott McNitt, MS, Xiaojuan Xia, MS,
Anthony Fossa, PhD, Britt M. Beckmann, MD, Slava Polonsky, MS, and Wojciech Zareba, MD, PhD, FACC

Comparison of Highly-Automatic versus FDA-Submitted
QT Measurementsfor the Detection of Moxifloxacin Induced
Prolongation of the QTc Interval (242 KB)
R Handzel, C Garnett, M Li, S McNitt, S Polonski, X Xia, JP Couderc

The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships (403 KB)
Anthony A. Fossa

Investigating the effect of sotalol on the
repolarization intervals in healthy young individuals (469 KB)
Jean-Philippe Couderc, PhD, Meijian Zhou, PhD,
Nenad Sarapa, MD, Wojciech Zareba, MD, PhD

Improving the Detection of Subtle IKr-Inhibition
Assessing Electrocardiographic Abnormalities of
Repolarization Induced by Moxifloxacin (273 KB)
Jean-Philippe Couderc, Scott McNitt, Ollivier Hyrien, Martino Vaglio, Xiajuan Xia, Slava Polonsky, Arthur J. Moss1 and Wojciech Zareba

QT Prolongation Modifies Dynamic Restitution and Hysteresis
of the Beat-to-Beat QT-TQ Interval Relationship during Normal
Sinus Rhythm under Varying States of Repolarization (742 KB)
Anthony A. Fossa, Todd Wisialowski, and Kimberly Crimin

Dynamic Beat-to-Beat Modeling of the QT-RR Interval
Relationship: Analysis of QT Prolongation during Alterations of
Autonomic State versus Human Ether a-go-go-Related Gene
Inhibition (2,272 KB)
Anthony A. Fossa, Todd Wisialowski, Anthony Magnano, Eric Wolfgang, Roxanne Winslow, William Gorczyca, Kimberly Crimin, and David L. Raunig

Impaired T-Amplitude Adaptation to Heart Rate Characterizes
IKr Inhibition in the Congenital and Acquired Forms
of the Long QT Syndrome (218kb)
JP Couderc, S McNitt, J Xia, W Zareba, A Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA

Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval (257kb)
JP Couderc, S McNitt, J Xia, W Zareba, A Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA

T-wave Morphology and Arrhythmic Events in Patients with Dilated Cardiomyopathy (194kb)
JP Couderc, W Zareba, X Xia, M Andrew, AJ Moss Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA

Fractionated Repolarization Induced by Sotalol in Healthy Subjects (103kb)
M Vaglio, JP Couderc, X Xia, W Zareba
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA

Beat-toBeat Repolarization Variability in LQTS Patients with the SCN5A Sodium Channel Gene Mutation (677kb)
JP Couderc, W Zareba, AJ Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA

Drug-induced Changes of Ventricular Repolarization: New Incentives for Quantifying T wave Morphology (134kb)
JP Couderc, W Zareba, AJ Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA

Discrimination of HERG Carrier from Non-Carrier
Adult Patients with Borderline Prolonged QTc Interval (108kb)
JP Couderc, W Zareba, AJ Moss
Heart Research Follow-up-Program, University of Rochester Medical Center, Rochester, NY, USA

PDF (195kb)
An editorial in the January 2006 issue of the Annals of Noninvasive Electrocardiology, prepared by Dr. Arthur J. Moss, describing the historical background and current thinking in the quantification of cardiac safety using QT interval measurements titled “Drug-Induced QT Prolongation: An Update.”

PDF (161kb)
An article by Drs. Couderc, Zareba, Moss et. al in the January 2005 issue of Annals of Noninvasive Electrocardiology describing the most robust method for determining an individual-based correction for QT interval titled “Assessment of the Stability of the individual-based Correction of QT interval for heart rate.”

PDF (218kb)
An article by Drs. Couderc, Zareba, Moss et. al in the Journal of Electrocardiology describing more advanced ECG markers titled “Identification of Sotalol-induced Changes
in Repolarization With T Wave Areabased Repolarization Duration Parameters.”

PDF (67kb)
FDA Guidance Document for QT Measurement in Clinical Trials Titled “Guidance for Industry: E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs.”

PDF (71kb)
FDA Guidance Document for Non Clinical Evaluation of Cardiac Risk in Clinical Trials Titled “Guidance for Industry: S7B Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals.”

View QT drug lists on the University of Arizona's CERT site

Drugs that Prolong the QT Interval and/or Induce Torsades de Pointes Ventricular Arrhythmia

PDF (67kb)
ICH E14 Q&A E14 Implementation Working Group - Questions & Answers

PDF (25kb)
QT IRT Reference Document

PDF (36kb)
QT IRT MAPP